Abstract
This experiment represents preliminary data of a study, the object of which is to determine the factors which affect the formation of glycuronic acid in the body.
A solution of menthol was made by dissolving 44 grams in enough warm olive oil to make a total volume of 66 cc. Six cc. portions were administered to rabbits through a stomach tube by means of a graduate syringe. Only healthy young animals were used.
The results indicate clearly that the glycuronic acid output may be decreased either by insulin or by phlorhizin. The normal output per rabbit after the above dose of menthol was about 4 grams of the crude ammonium menthol glycuronate. Under the same conditions, but with insulin and glucose, the output was only about 2.6 grams per rabbit. When starved and phlorhizinized, similar results were obtained, as in the case of insulin. This appears to indicate a relation between the amount of carbohydrate in the tissue and the extent of synthesis of glycuronate.
Get full access to this article
View all access options for this article.