Abstract
Summary
1. Fischer line 344 female rats were fed 2-acetylaminofluorene in synthetic diets containing 25% casein and supplements of 1.4% DL-tryptophan; 1.0% indole acetic acid; 0.8% indole and 1.6% indole. Liver cancers developed in 91% of the rats of the first group and in 83% of the rats of the other 3 groups. 2. The majority of the liver neoplasms in the rats that received 1.4% DL-tryptophan and 1.0% indole acetic acid were malignant hepatoma and lung metastases were present in 63% and 90% respectively. 3. The majority of the liver neoplasms in the rats that received 0.8% and 1.6% indole were cholangioma or adenocarcinoma and lung metastases from these tumors were identified in 38 and 12%, respectively. 4. Cancers of the urinary bladder were observed in 75% of the rats that received 1.4% DL-tryptophan; 58% of the rats that received indole acetic acid and in 83% of the rats that received indole. Indole appeared to be as effective as dietary tryptophane in the initiation of the bladder neoplasms. 5. The cancers of the urinary bladder were papillary or squamous cell carcinoma.
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