Metabolism of dl-Adrenaline-2-C 14 in the Human ∗ †

Abstract

Summary

A procedure is described which utilizes a combination of filter paper and ion exchange chromatography to separate the urinary metabolic products of adrenaline. After intravenous infusion of dl-adrenaline-2-C¹⁴ in 6 human subjects, 73 ± 5% of infused radioactivity was recovered in 24 hour urine. Radioactivity which appeared in urine was distributed among various metabolic products as follows: adrenaline, 4%, 3-methyl-O-adrenaline, 5%, 3-methyl-O-adrenaline conjugate, 42 ± 7%; 3-methoxy-4-hydroxymandelic acid, 27 ± 3%; 3, 4-dihydroxymandelic acid, 12 ± 4%; 2 unidentified fractions, 4%.