Abstract
Summary
The incidence of mammary cancer and average cancer age have been determined in the following groups of AZ F1 hybrid mice: 1) sham ovariectomized non-breeding females; 2) ovariectomized females bearing their own ovaries transplanted; 3) hypophysectomized - castrate males bearing transplanted ovaries and female pituitaries; 4) hypophysectomized-castrate males bearing transplanted ovaries and male pituitaries. The results showed no significant differences in cancer incidence between any of the groups studied. However castrate males with transplanted ovaries developed cancer significantly earlier than did the females regardless of the sex of the pituitary gland they carried. Therefore it was tentatively concluded that the greater susceptibility to breast cancer observed in males is not dependent upon the sex of the hypophyseal gland per se but rather on a sex difference in some other structure controlling the hypophysis.
Get full access to this article
View all access options for this article.