Abstract
Summary
Heart mitochondria from dogs in irreversible hemorrhagic shock and from paired control animals were analyzed for protein, nitrogen and phosphate and their absorption spectra were compared. Similar analyses were done on water and perchloric acid extracts. The results indicate that, in shock, mitochondria accumulate abnormal amounts of phosphate, some of it in a form which is soluble in perchloric acid and reacts as inorganic phosphate under Fiske-Subbarow conditions. Simultaneously, some of the intramitochondrial proteins become more readily extractable with water.
Get full access to this article
View all access options for this article.