Abstract
Summary
Rats given lethal doses of total-body X-irradiation were treated with liver cells obtained from rat and rabbit embryos. Two to 7 weeks after this treatment, groups of animals were stimulated with a mixture of Bovine Serum Albumin and Salmonella typhi vaccine intravenously. Rats were bled 1 week after antigen injections and titers were performed for detection of antityphoid and anti-BSA antibody. Rabbit-treated rats showed a positive titer to BSA and a delay in recovery of antibody-forming capacity to both antigens administered. Although rat-treated rats recovered their antibody-forming capacity earlier, they did not show any response to BSA. Possible implications of these phenomena are discussed.
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