Abstract
Summary
Phosphorylation processes were studied in heart and brain mitochondria of rats subjected to severe shock by the Noble-Collip drum, tourniquet and hemorrhage technics. A decreased synthesis of adenosine-triphosphate was found in drum shock. Lowered P/O ratios were obtained with heart mitochondria of all 3 types of shock when compared to normal preparations, and the adenosine-triphosphatase activity was unchanged. After shock, the electrolyte composition of heart mitochondria was altered; the total phosphorus and potassium increased while sodium decreased and magnesium and calcium showed only slight differences. The relationship of these findings to the structure and function of mitochondria in shock are discussed.
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