Comparative Study of Uptake and Distribution of Hg 203 Given as Labelled Chlormerodrin (Neohydrin). ∗ †

Abstract

Summary

The uptake and distribution of Hg²⁰³ given as labelled chlormerodrin (Neohydrin) has been studied in the mudpuppy, carp, bullfrog, turtle, chicken and dog. Preferential binding of radiomercury by renal tissue was found in all animals with most tissue/plasma ratios of Hg²⁰³ well above one. For a given dose poikilothermic animals showed a slower accumulation and loss of radiomercury than did homoiothermic specimens. With the exception of the dog, in all animals there was only a slow fall in renal content of radiomercury over a time period of 46 to 70 hrs. In Necturus maximum mercury uptake was found in a part of the kidney made up predominantly of proximal tubules.