Abstract
Summary
1. Pantothenic acid deficiency was induced in guinea pigs by feeding deficient diet to which omega-methyl pantothenic acid, a vitamin antagonist, was added. 2. Urinary excretion of adrenocortical hormones by pantothenate depleted guinea pigs was compared with that of pair-fed controls and was significantly reduced. 3. Excretion of 17-hydroxycorticosteroids by pantothenic acid deficient guinea pigs was significantly decreased when compared with that of ascorbic acid depleted animals. 4. Diminished adrenocortical hormone secretion which occurred in these animals was a specific effect of pantothenic acid depletion and not a non-specific manifestation of nutritional deficiency.
Get full access to this article
View all access options for this article.