Abstract
Summary
1. The Schultz-Dale reaction in egg white or BSA sensitized guinea pig uterus or ileum persisted in the presence of serotonin antagonists LSD and BOL. 2. Anaphylactic contraction of these tissues could be partially or completely blocked with varying concentrations of yohimbine, gramine and bufotenine, but the reaction to histamine was affected similarly. 3. It was impossible to demonstrate the release of serotonin from sensitized guinea pig lung, uterus or ileum in the presence of highly serotonin sensitive mouse uterus. 4. Persisting anaphylactic contraction of histamine-poisoned guinea pig uterus was not diminished in the presence of BOL or LSD.
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