Abstract
Summary
The resistance of strains of S. typhi to the bactericidal action of normal guinea pig, rabbit, and human serum was determined. The order of resistance of the strains to sera of different species was in close agreement, but human sera exerted a greater bactericidal effect than rabbit or guinea pig sera. The resistance of the strains containing both O and Vi antigens was associated with the O-inagglutinability or Vi content of the organisms. The natural bactericidal antibodies against S. typhi were of marked specificity and directed against either the O or R antigens. The resistance of the strains to phagocytin or to chloramphenicol did not correlate with their resistance to normal serum components.
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