Iodine-131 Labeled Cholografin Studies in Dogs with Normal and Abnormal Liver Physiology

Abstract

Conclusion

1) After injection of cholografin tagged with I¹³¹ in normal dogs and in dogs with altered liver function, there are sufficient differences in concentration of radioactivity in the liver to warrant further investigation of this material as a possible liver function test in human patients. Significant differences are also noted in the clearance rate of radioactivity from the blood and excretion in the urine.