Sensitivity of the Common Bile Duct to Acid Peptic Digestion. ∗

Abstract

Summary

1. The glandular mucosa of common bile duct shows a sensitivity to acidpeptic digestion at least as great as that of the esophagus. 2. Admixture of bile and pancreatic juice incubated from 1/2 to 48 hours failed to demonstrate evidence of digestive injury to either the common bile duct or the esophagus during a 2-hour period of perfusion. 3. There would appear to be a possibility that acid-peptic erosion of the biliary papilla may play a role in the genesis of stricture of the bile duct in some disease states.