Abstract
Summary
Substrains isolated on the basis of colonial morphology from antigenically homogeneous cultures of Sh. dysenteriae and E. coli displayed stable genetic differences in resistance to the bactericidal effects of normal human serum. This serum resistance was inversely correlated with penicillin resistance: with increased resistance to the antibiotic there was an increased susceptibility to serum. Mechanisms that may be responsible for this relationship, and their bearing on certain problems of in vivo penicillin resistance, have been discussed.
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