Abstract
Summary
The lipotropic and lipide phosphorylating effects of choline, betaine, and inositol were compared in rats maintained on low protein-low fat or low protein-high fat diets. All 3 agents (100 mg supplements/rat/day) were equally effective in causing a significant reduction of total lipides over controls in animals maintained on the low protein-low fat diet. Only choline and betaine supplements caused a substantial reduction of total liver fat in rats maintained on the high fat diet. Phospholipide synthesis was increased when choline, betaine, or inositol was administered as a single dose (0.4 mM) to animals maintained on the low protein-low fat diet. The order of effectiveness upon turnover rate was choline > betaine > inositol. Both choline and betaine, when administered as single doses, stimulated lipide phosphorylation in rats on the high fat diet, but inositol did not.
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