Abstract
Summary
1) C-4 substituted testosterone analogs possess potent myotrophic and weak androgenic activity as measured by increase in weight of levator ani muscle and ventral prostate gland, respectively. 2) Daily subcutaneous injections of 0.5 mg 4-chlorotestosterone acetate induce greater anabolic and lesser androgenic effects than similarly administered testosterone propionate; the anabolic/androgenic ratios are 0.62 for the former and 0.27 for the latter. 3) The anabolic activity of the 4-chloro-19-nortestosterone acetate and 4-chloro-19-nortestosterone cyclopentyl propionate is equivalent to that of testosterone propionate, but their effect on prostate growth is less. The anabolic/androgenic ratios are 1.16 and 2.10 respectively. 4) Neither 4-chlorotestosterone actetate nor 4-chloro-19-nortestosterone acetate has estrogenic or corticoid activity. Only the latter, however, has progestational activity.
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