Abstract
Summary
1. Introduction of exogenous citric acid in a neutralized rinsing fluid into the peritoneal cavities of normal, nephrectomized and parathyroidectomized-nephrectomized male rats was studied. Normal rats survived relatively large amounts of citric acid. Nephrectomized rats were able to survive amounts of citric acid up to 0.50%; parathyroidectomized — nephrectomized rats only up to 0.20%. 2. Normal, nephrectomized, and parathyroidectomized animals showed increases in wash calcium when optimal amounts of citric acid were present in the rinsing fluid. Parathyroidectomized -nephrectomized rats given the same amount of citric acid in the rinsing fluid were found to have higher wash citric acids but lower wash calciums than their nephrectomized controls. In each group of rats the highest calcium and citric acid levels usually occurred in the first wash. Subsequent washes generally showed progressively smaller amounts of calcium and citric acid, even though the amount of citric acid in the rinsing fluid was never changed within a group throughout all the rinsings. Possible explanations are discussed.
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