Abstract
Summary
1. The cytotoxicity of 3 tuberculoproteins, PPD, T(NY), and C, for tuberculin-sensitive macrophages has been compared in tissue culture. All 3 tuberculoproteins had cytotoxic properties in vitro. No differences were observed between in vitro effects of each of the tuberculoproteins at any one concentration. 2. Each tuberculoprotein had a definite observable cytotoxic and inhibitory action on tuberculin-sensitive splenic macrophages at low concentration of 1 γ/ml, but none at 0.1 γ/ml. 3. Skin test reactions in sensitized guinea pigs to the 3 tuberculoproteins gave similar results.
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