Ammonia Excretion and Renal Glutaminase Activity During Administration of Strong Acid and Buffer Acid. ∗

Abstract

Conclusions

Activation of renal glutaminase during administration of NH₄C1 does not appear to result from pre-renal effects of the acid load, since physiologically equivalent loads of NaH₂P0₄ produced the same slight depression of serum bicarbonate but affected neither excretion of ammonia nor activity of renal glutaminase. Rather, it appears that activation of glutaminase is related to changes, as yet unidentified, within the kidney.