Abstract
Summary
Injection of 2 billion H. pertussis cells into T. F. female mice increases susceptibility of these mice to cold stress. 2. Susceptibility to cold of pertussis-treated mice is greater than that of adrenalectomized mice. 3. Adrenalectomy of pertussis-treated mice increases susceptibility to cold stress to a greater extent than either treatment alone. 4. Sham-operated animals whether normal or pertussis-treated are neither more resistant nor more sensitive to cold stress than similarly treated but unoperated animals. 5. Cortisone and hydrocortisone protect pertussis-treated mice from cold stress but to a lesser degree than they protect adrenalectomized mice. 6. Increasing the amount of hydrocortisone from 2 to 6 mg has little effect on increasing the protective effect of this drug. 7. Hydrocortisone given to normal mice increases their resistance to cold. 8. It is suggested that while pertussis possibly affects adrenal function, it must in addition affect other functions in the mouse which are also concerned with protection against stress.
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