Adrenal Corticoid Activities of 6-Methyl-Δ 1 -Hydrocortisone

Abstract

Summary

Comparisons are presented on relative potencies of Δ¹-F and a new analogue, 6-methyl-Δ¹-F, on 3 different assays for corticoid activity: anti-inflammatory (granuloma pouch technic), liver glycogen deposition, and sodium retention. 6-Methyl-Δ¹-F is 2 times as potent as Δ¹-F on the anti-inflammatory test and about 3 times Δ¹-F on the glycogen deposition assay. 6-Methyl-Δ¹-F, like Δ¹-F, does not induce sodium and water retention on the assay for electrolyte activity, but in contrast to Δ¹-F, this steroid acts as a diuretic and natriuretic agent.