Tolerance of the Rat for N,N'-Diphenyl-P-Phenylenediamine

Abstract

Summary

Inclusion of N, N'-diphenyl-p-phenylenediamine in a vit. E-low diet fed to female rats through growth and reproduction has resulted in varying degrees of reproductive failure. Toxicity was encountered during growth at a level of 0.5% but not at 0.1% or below. Rats receiving 0.1% dppd exhibited uterine and vaginal hemorrhages at parturition accompanied by anorexia, anemia and emaciation. Concentrations of 0.025%, 0.01% and 0.005% resulted in a high incidence of stillbirths. No adverse effects were encountered from feeding 0.0006% dppd in the diet. The data show that dppd elicits symptoms of toxicity in the rat at concentrations below those used in commercial mixed feeds.