Effect of N-Allylnormorphine Upon Massive Doses of Narcotic Drugs

Abstract

Summary

Nalorphine is an effective antidote for doses of opiates which would otherwise be lethal, in those instances where signs of depression are the dominant toxic manifestations. It is relatively ineffective, however, in those instances where convulsions are a prominent feature. In rabbits and mice receiving convulsant doses of meperidine, codeine or prisilidene, nalorphine alone was seldom life-saving, but administration of both phenobarbital and nalorphine adequately protected the animals. Codeine and prisilidene did not produce convulsions in rats; nalorphine alone was an effective antidote in these instances.