Abstract
Summary
A morphological alteration of yeast-like cells of C. albicans and C. stella-toidea has been shown to occur within 1 hour after injection into the subcutaneous tissues of mice. Yeast-like cells of other members of the genus Candida failed to exhibit these alterations under the same conditions. The yeast-like cells of C. albicans had formed elongated pseudomycelia within 1 hour after injection. At later times considerable growth of these filaments with the appearance of septa was observed. Other species of the genus Candida retained their typical yeast-like morphology. It has been postulated that filamentation of C. albicans in vivo serves as a hindrance to ingestion by mouse phagocytes. The results suggest a significant role for these morphologically altered organisms in the pathogenesis of experimental moniliasis in the mouse.
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