Abstract
Summary
Acidified boiled filtrates were prepared of plasma, liver, spleen, thymus. lung, brain, skeletal muscle, bone marrow and packed blood cells of rabbits made severely anemic by phenylhydrazine. When tested in normal rats, only the plasma extracts proved to be erythropoietiC., as evidenced by significant elevations in peripheral red cell, hema-tocrit and reticulocyte values as well as by a marked increase in the percentages of marrow nucleated erythrocytes. The site of formation of circulating ‘erythropoietin’ remains unidentified.
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