Abstract
Summary
1. Mice pretreated with various amounts of heparin exhibit resistance, relative to heparin dose, to the toxic effects of subsequent injections of otherwise lethal doses of 48/80. There is a straight-line relationship between the 50% protective heparin pretreatment doses and the various 48/80 challenge doses. 2. Fibroblasts exposed to the heparin-48/80 complex rapidly sequester and deposit this material as metachromatic granules in their cytoplasm. 3. The possible significance of these results is discussed.
Get full access to this article
View all access options for this article.