Nithiazide II. Effect on Enterohepatitis in Turkeys

Abstract

Summary

1. The data presented show that nithiazide [1-ethyl-3-(5-nitro-2-thi-azolyl) urea | was more potent and less toxic than 2-amino-5-nitrothiazole when fed to turkeys with enterohepatitis. 2. Nithiazide was most effective when administered prior to infection or beginning 3 to 7 days after infection. It prevented mortality from enterohepatitis produced either by oral exposure to cecal worm eggs or by rectal inoculation of Histomonas meleagridis cultures. Nithiazide may be administered in the feed or water and is equally effective in either form. 3. The therapeutic feeding of rations containing 0.05% nithiazide, starting 3 days after infection, prevented mortality from infectious enterohepatitis which was lethal for 73% to 83% of the untreated control turkeys.