Effect of Choline on Phosphatide Metabolism of Gholine-Deficient and Cholestero-Fed Rabbits. ∗

Abstract

Summary

In rabbits maintained on a high-fat, low-protein, choline-deficient diet for a period of 14 days, the synthesis of liver phosphatides was markedly increased. A single dose of intravenous choline was associated with a further increment in phosphatide synthesis, while chronic choline supplements depressed liver phosphatide synthesis. The plasma phosphatide concentration and synthesis were markedly elevated in all the fat-fed animals. The aortic phosphatide synthesis remained unaltered. Choline administration to cholesterol-fed rabbits did not alter the plasma or liver phosphatide metabolism.