Abstract
Summary
1. Intravenous injection of 0.3 γ/min. 5-hydroxytryptamine creatinine sulfate (5-HT) caused transitory elevation of local venous pressure; higher doses induced more marked elevation of local venous pressure and, when administered in short period of time, of arterial pressure. Elevation of systemic venous pressure was not obtained even with extremely high doses of 5-HT. 2. Intraarterial administration of 5-HT induced sustained elevation of pressure in the homolateral veins (30 minutes or longer). 3. Elevation of arterial pressure and generalized flushing followed injection into a patient with septal venous-arterial shunt of a dose of 5-HT unable to cause such effect in normal subjects. 4. It is postulated that injected 5-HT is quickly removed from the circulation, perhaps by platelets or by other cellular elements retained in capillary beds and released slowly at a later time.
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