A Broncho-Constrictor Factor in Cigarette Smoke

Abstract

Summary and Conclusions

Experiments on intact guinea pigs indicate that cigarette smoke contains a broncho-constrictor agent. The intensity of the broncho-constrictor response is different with different lengths of cigarettes. Evidence is presented which indicates that the active agent in the smoke is not nicotine. Experiments using 2 brands of filter-tipped cigarettes indicated that the filter-tip did not influence the response of the lung to the cigarette smoke. The single brand of “denicotinized” cigarettes showed significantly less total broncho-constrictor effect than did the conventional cigarettes.