Abstract
Summary
The total lack of isoleucine in the diet of rats resulted in regression in the size of the pituitary acidophils, deletion of the pituitary gonadotrophic cells, atrophy of the testes and accessory sex glands, thymic involution, interference with somatic growth, liver glycogen accumulation and degenerative changes in skeletal muscle. Replacement of adequate isoleucine to the diet of isoleucine-deficient rats resulted in complete recovery.
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