Abstract
Summary
(1) Influenza and mumps viruses induced increased numbers of histiocytes in the allantoic fluids of embryonated eggs. The significance of this response was enhanced by coincident hemagglutinin production and by an interference effect on both responses by specific antiserums. (2) Nasal washings from acute common cold (afebrile rhinitis) patients engendered increased numbers of histiocytes in the allantoic fluid of embryonated eggs. The agent(s) responsible for this cytological response were thermolabile, were not inhibited by penicillin and streptomycin, and produced no detectable growth in bacteriological media. The agent (s) were not demonstrable in nasal washings collected from the same patients during convalescence. (3) Nasal washings from cases of acute allergic rhinitis did not induce increased numbers of histiocytes in the allantoic fluid of inoculated eggs.
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