Abstract
Summary
Male albino rats were fed diets for 28 days in which the type of carbohydrate was varied and serum cholesterol and beta-lipoproteins were determined. 1. Rats fed diets containing sucrose as the carbohydrate and with added cholesterol and cholic acid had higher serum cholesterol and serum beta-lipoprotein concentrations than did control rats fed diets with corn starch substituted for sucrose. Liver cholesterol concentrations were not significantly different. 2. Feeding of sucrose, glucose, and fructose as the dietary carbohydrate had essentially equal effects on cholesterol-cholic acid induced hypercholesteremia. 3. Rats which were fed cholesterol containing diets without cholic acid and with corn starch as the carbohydrate had somewhat lower serum cholesterol values than did the controls which were fed sucrose. 4. When sulfasuxidine was added to sucrose containing diets, there was no change in serum cholesterol values; however, addition of sulfasuxidine to starch containing diets resulted in elevation of serum cholesterol values to the level of that in rats fed sucrose.
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