Abstract
Summary
1. Intravenous administration of protamine markedly increases the amount of slowly infused thromboplastin required for defibrination of dogs. Protamine given during infusion of thromboplastin, to a dog already partially depleted of fibrinogen, arrests further decrease in plasma fibrinogen level. 2. Intravenous administration of protamine protects dogs from the lethal effect of subsequent rapid injection of thromboplastin. 3. Mode of action of protamine and possible clinical utilization of its antithromboplastic properties are discussed.
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