Abstract
Summary
1. Humans and rats receiving a purified laboratory diet excrete hippuric acid, 1 to 3 mg/kg/day. This amount appears to be formed endogenously and its excretion in the rat is not affected by fasting, by inclusion of sulfasuxidine in the diet, or by injection of phenylalanine. 2. 0.05% of the radioactivity of 3-C14-L-phenylalanine injected into a rat was excreted in 24 hours in the form of hippuric acid. Further experiments suggested that endogenous hippuric acid could not be derived from phenylalanine in any direct manner.
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