Hyperactivity of Metachloridine against Plasmodium gallinaceum in Chicks Maintained on a Purified Diet. ∗

Abstract

Summary

1. The erythrocytic form of the malarial parasite Plasmodium gallinaceum was found to grow at a comparable rate in chicks fed either a purified diet (C-2) or a commercial stock diet. The antimalarial activity of 7 compounds was approximately the same in parasitized chicks fed either of the above diets, while sulfadiazine and metachlor-idine exhibited a marked increase in effectiveness in those chicks fed the C-2 diet. 2. The hyperactivity of metachloridine in chicks fed the C-2 diet was reversed almost completely when this diet contained 41% soybean meal. Neither the fatty nor protein fractions of soybeans, nor several other dietary nutrients appeared to contain significant amounts of the inhibitor.