Inhibition of Development of Chick Embryo Liver by Aminoguanidine

Abstract

Summary

Aminoguanidine sulfate when injected into the yolk of a 4-day embryonated egg produced a severe inhibition of liver development of the chick embryo when the specimens were examined 10 days later. Apparently, the parenchymal cells were the sites of inhibition as the surviving tissue, in addition to being reduced in mass, was composed largely of connective tissue and cystic structures. Other organs and tissues of the specimens appeared to be relatively unaffected. The most effective sub-lethal dose at 4 days incubation was ineffective when administered at 9-10 days of incubation. Other hydrazides possess peculiar effects which bear no resemblance to that of AGS.