Production of Arteriosclerosis in Birds by the Prolonged Feeding of DihydrocholesteroL ∗

Abstract

Summary

1. The feeding of a diet containing 0.5% dihydrocholesterol (DHC) for 6 months resulted in the development of severe arteriosclerosis of the thoracic and abdominal aortas in 12 birds. 2. The aortic lesions observed were identical with those induced in the bird by the feeding of cholesterol, and appeared to have resulted from deposition of dihydrocholesterol in the vascular wall. 3. Hepatic enlargement in DHC-fed birds was similar to that observed previously in cholesterol-fed birds, and was due in part to reticuloendothelial storage of dihydro-cholesterol.