Abstract
Summary
The Pharmacological properties of Recanescine, a new alkaloid recently isolated from Rauwolfia canescens, have been found to be similar to reserpine and rescinnamine. Recanescine produces hypotension, bradycardia and sedation accompanied by characteristic alterations in cardiovascular responses. These are depression of the pressor response to bilateral carotid occlusion and blockade or reversal of the pressor response to central vagal stimulation. The sedative effects of Recanescine have been observed grossly in dogs and mice, and they have been demonstrated objectively in mice by prolongation of pentobarbital induced sleeping time and by increased “fall-outs” from roller cages. Recanescine significantly raised the tolerance of mice to toxic doses of amphetamine. This has been interpreted as due to the sedative effect of this alkaloid.
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