Abstract
Summary
1. Esophageal perforations, similar in many respects to the so-called “spontaneous” perforations of the esophagus seen in humans, can be caused in dogs by ligation of the outlet of the stomach followed by intramuscular administration of histamine-in-beeswax. 2. The incidence of esophageal perforation is far higher following pyloric obstruction in dogs that have a double-barrelled cervical esophagostomy prior to pyloric ligation. Presumably this is due to the loss of the protective effect of the saliva. 3. Excision of the acid-secreting segment of the stomach not only prevents esophageal perforation following pyloric ligation, but also completely prevents the development of any esophagitis.
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