Abstract
Summary
1. Concentrations of liver lipid components, and liver, muscle and plasma electrolytes, glycogen and glucose were determined at 4, 24, and 72 hours after alloxan injection in adrenalectomized groups of rats. One series was maintained with 1% NaCl and a second series received daily injections of small levels of Lipo-adrenal extract in addition to the saline. In both series a moderate hyperglycemia was extant at 72 hours after alloxan; but at 4 and 24 hours the blood glucose levels were only slightly or not different from the controls. This was in marked contrast to the hyperglycemia found in intact rats at these intervals after alloxan. 2. In contrast to the changes in concentration in liver lipid components and liver and plasma electrolytes found in intact rats after alloxan at these periods, adrenalectomy apparently effectively prevented their occurrence. 3. An increase in the exogenously administered dose of adrenocortical material just before alloxan injection resulted in significant alterations in liver lipid components as well as increased potassium concentration in plasma, muscle, and liver.
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