Inhibition of in vitro Heme Synthesis from N 15 -Glycine by 2-Ethyl-5-methylbenzimidazole. ∗,†

Abstract

Summary

2-Ethyl-5-methylbenzimidazole was found to be considerably more inhibitory than 2,5-dimethylbenzimidazole, or benzimi-dazole, for the synthesis of heme by chicken erythrocytes incubated in vitro. This was in the same relative order of inhibitory activities as was noted for multiplication of influenza A or B virus, and is considered to add further support to the concept that the same basic mechanism, possibly involving a fundamental role of nucleic acid in biosynthesis, underlies both processes.