Abstract
Summary
The administration of a gelatin-stabilized carbon suspension did not affect bromsulfalein (BSP) clearance in dogs. However, a carbon-free nitrate of Higgins India ink markedly inhibited BSP uptake and effected the release of previously stored BSP from the liver. It appears that the effect of India ink on BSP excretion is not due to reticuloendothelial blockade but rather to a toxic effect of some soluble component of the ink on the liver. It is suggested that in dogs BSP clearance is not a suitable index of Kupffer cell activity.
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