Abstract
Summary
1. Ascorbic acid at 1 g/kg when administered prior to vanadium antagonizes the toxicity of vanadium as NaVO3 · H2O in mice at the LD70 and LD95 levels. Dosage levels as low as 125 mg/kg ascorbic acid showed a protective action against the LD70 of NaVO3 · H2O in mice. 2. Antidotal effects of calcium disodium ethylenediamine tetraacetate and ascorbic acid have been demonstrated in vanadium-poisoned rats and dogs, after signs of toxicity had become manifest. 3. Ascorbic acid is probably the more rapidly-acting of the 2 antidotes. Signs of vanadium toxicity were present for a longer period of time in vanadium-poisoned animals after CaNa2EDTA than after ascorbic acid administration. 4. One possible mode of detoxication of vanadium by ascorbic acid is suggested, on the basis of in vitro polarographic studies, to be reduction of the vanadium.
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