Abstract
Summary
Changes in the total DNA, protein nitrogen, the RNA/DNA ratio and water content have been studied in the uteri of mice of strain 129 from 1 to 14 months of age. RNA/DNA (an estimate of relative RNA per cell) at the stimulated stages of the estrous cycle is maximal at the time of maximal uterine growth, between 2I/2 and 5 months of age. The RNA/DNA of the uterus at the stimulated stages is higher than at diestrus at all ages. However, the differences between the diestrous values and that reached by the ratio at the stimulated stages slowly decreases with age. The cellular RNA content is significantly correlated with the water content of the uterus under the conditions studied here and is also positively correlated with the amount of protein nitrogen synthesized.
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