Passage of Metabolites of Chloral Hydrate into Amniotic Fluid

Abstract

Summary

The results indicate that in the early stage of pregnancy chloral hydrate and its metabolites pass from the blood into the amniotic fluid. However, urochloralic acid, which is the form by which chloral hydrate is excreted by the kidneys, was found also at a stage when the gestation had progressed to two-fifths. In later pregnancy only urochloralic acid was found, which indicates that in the later stages the amniotic fluid contains essentially the products of foetal renal excretion.