Abstract
Summary
1. Trypsin converts prothrombin into thrombin. Calcium and accessory clotting factors are not essential. Calcium does, however, accelerate the rate of thrombin formation but without affecting the thrombin yield. 2. Conversion of prothrombin by trypsin is incomplete. 3. Heparin, in low concentrations, can inhibit the clotting effect of trypsin by increasing plasma antithrombic activity.
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