Abstract
Summary and Conclusions
A 5- to 10-fold increase in the activity of chorionic gonadotroph as measured in rats, was produced by the in vitro addition of unaltered human plasma. Similar augmentation was observed when the hormone was mixed with boiled human plasma, rat serum, egg white and polyvinylpyrollidone. The augmenting abilities of plasma obtained from 2 hypogonadal individuals, the one having high, the other having low endogenous gonadotrophin levels, was no different than that of plasma obtained from normal individuals. Enhancement of hormonal activity did not occur when “augmentor” and hormone were kept separate and injected at different subcutaneous sites. It is concluded that the most likely mechanism of augmentation is prolongation of absorption from the site of injection.
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