Abstract
Discussion and Summary
A simple technic is described whereby the production of plaques in chick embryo tissue cultures has been consistently obtained with vaccinia virus. The plaques are probably due to viral activity. This conclusion is supported by the fact that 1) the plaques are absent when the virus is absent and their number increases with the concentration of the virus, 2) the number of plaques produced intissue culture correlates with the number of pox produced on the CAM of the developing chick embryo and 3) specific antibody reduces both the number of plaques formed in tissue culture and the number of pox formed on the CAM by 95%.
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