Abstract
Summary
1. The influence of benzimidazole on experimental poliomyelitis in mice and monkeys was investigated. The subcutaneous administration of 250 mg/kilo prolonged the incubation period of infection with the Lansing strain of Type 2 poliomyelitis in mice and reduced the mortality caused by minimal quantities of this virus. 2. Infection of adult mice with intracerebrally inoculated MEF-1 strain of Type 2 virus was not affected by this compound which even appeared to enhance infection in suckling mice inoculated intraperitoneally with this same strain. 3. In monkeys the incubation period of infection with the Mahoney strain of Type 1 virus was prolonged slightly by limited treatment with benzimidazole, but the mortality was not reduced. More intensive treatment was without effect. 4. The advisability of further work with this and structurally similar compounds is discussed.
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